Episode 3: Change Changing Places

Original Publish Date

February 17, 2021

Episode Description

Does CMT change types from one generation to the next? Can CMT change types? Can somebody inherit a different type of CMT than what their mom or dad has? The answers are easy, but getting to the why and how behind the answer requires a little bit of digging.

Episode 3: Change Changing Places

Show Notes

In this episode, we tackle the questions about CMT changing types through inheritance and explain the how and why behind some families having more than one type of CMT.

Sources

Johns Hopkins Online Mendelian Inheritance in Man (OMIM) CMT Phenotype Series
https://www.omim.org/phenotypicSeries/PS162400

What is a Chromosome?
https://www.genome.gov/genetics-glossary/Chromosome

What is an Autosome?
https://www.genome.gov/genetics-glossary/Autosome

Inheritance Patterns and Mutation Types:
https://www.ncbi.nlm.nih.gov/books/NBK115561/


A Gene’s Home Address:
https://medlineplus.gov/genetics/understanding/howgeneswork/genelocation/

The Human Genome Project
https://www.genome.gov/

The Cryptid Sloth Show Ep 1: It’s All In The Genes:
https://thecryptidslothshow.buzzsprout.com/1550245/7360330-ep-1-it-s-all-in-the-genes

The Human Genome Project:
https://www.genome.gov/human-genome-project


CMT Type Categories and Associated Subtypes

CMT1:
https://www.thecryptidsloth.com/cmt1

CMT2:
https://www.thecryptidsloth.com/cmt2

CMT4:
https://www.thecryptidsloth.com/cmt4

X-Linked CMT:
https://www.thecryptidsloth.com/cmtx

Dominant Intermediate CMT:
https://www.thecryptidsloth.com/cmt-di

Recessive Intermediate CMT:
https://www.thecryptidsloth.com/cmt-ri

HNPP:
https://www.thecryptidsloth.com/cmt1/hnpp

https://www.cmtausa.org/understanding-cmt/types-of-cmt/hereditary-neuropathy-with-liability-to-pressure-palsies-hnpp/


Referenced CMT Types

CMT1A: https://www.thecryptidsloth.com/cmt1/cmt1a

CMT4H: https://www.thecryptidsloth.com/cmt4/cmt4h



Additional CMT Resources

Find Your Nearest Charcot-Marie-Tooth Association Centers of Excellence CMT Clinic:
https://www.cmtausa.org/living-with-cmt/find-help/cmta-centers-of-excellence/

The CMTA’s Ask the Expert Desk:
https://www.cmtausa.org/living-with-cmt/find-help/ask-the-expert/

The Inherited Neuropathies Consortium:
https://www.rarediseasesnetwork.org/cms/inc/

The Hereditary Neuropathy Foundation
https://www.hnf-cure.org/